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Article

Hyperproliferation of mitotically active germ cells due to defective anti-Müllerian hormone signaling mediates sex reversal in medaka.

Development (Cambridge, England) - 1 Jul 2012

Nakamura Shuhei, Watakabe Ikuko, Nishimura Toshiya, Picard Jean-Yves, Toyoda Atsushi, Taniguchi Yoshihito, di Clemente Nathalie, Tanaka Minoru

Abstract excerpt

The function of AMH (Anti-Müllerian hormone), a phylogenetically ancient member of the TGFβ family of proteins, in lower vertebrates is largely unknown. Previously, we have shown that the gene encoding the type II anti-Müllerian hormone receptor, amhrII, is responsible for excessive germ cell proliferation and male-to-female sex reversal in the medaka hotei mutant. In this study, functional analyses in cultured...

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Source

Identifiers

PMID: 22627284
DOI: 10.1242/dev.076307

Genes

AMH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Hyperproliferation of mitotically active germ cells due to defective anti-Müllerian hormone signaling mediates sex reversal in medaka.PMID 22627284Read ↗

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