Article
Allogeneic bone marrow transplantation in models of experimental autoimmune encephalomyelitis: evidence for a graft-versus-autoimmunity effect.
Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation - 1 Jun 2007
Van Wijmeersch Bart, Sprangers Ben, Rutgeerts Omer, Lenaerts Caroline, Landuyt Willy, Waer Mark, Billiau An D, Dubois Bénédicte
Abstract excerpt
Autologous hematopoietic stem cell transplantation (HSCT) is being explored in the treatment of severe multiple sclerosis (MS), and is based on the concept of "resetting" the immune system. The use of allogeneic HSCT may offer additional advantages, such as the replacement of the autoreactive immune compartment by healthy allogeneic cells and development of a graft-versus-autoimmunity (GVA) effect. However, in...
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