Rapid emergence of a viral resistant mutant in WHV chronically infected woodchucks treated with lamivudine and a pre-S/S CHO-derived hepatitis B virus vaccine.

doi:10.1016/j.vaccine.2007.04.030

Article

Rapid emergence of a viral resistant mutant in WHV chronically infected woodchucks treated with lamivudine and a pre-S/S CHO-derived hepatitis B virus vaccine.

Vaccine - 21 Jun 2007

D'Ugo Emilio, Kondili Loreta A, Canitano Andrea, Catone Stefania, Giuseppetti Roberto, Gallinella Bruno, Palmieri Giampiero, Orobello Sara, Argentini Claudio, Glück Reinhard, Rapicetta Maria

Abstract excerpt

To determine whether the addition of a pre-S/S human vaccine increases the antiviral activity of lamivudine, four woodchucks were treated with a daily dose of 100 mg/kg lamivudine and four 50 microg doses of CHO-derived pre-S/S human vaccine. WHV DNA titres decreased up to two logarithms in three woodchucks. At week 4, in three of the animals, the sequence analysis showed a predominant strain containing a...

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Rapid emergence of a viral resistant mutant in WHV chronically infected woodchucks treated with lamivudine and a pre-S/S CHO-derived hepatitis B virus vaccine.

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