Article
Effects of age and viral determinants on chronicity as an outcome of experimental woodchuck hepatitis virus infection.
Hepatology (Baltimore, Md.) - 1 Jan 2000
Cote P J, Korba B E, Miller R H, Jacob J R, Baldwin B H, Hornbuckle W E, Purcell R H, Tennant B C, Gerin J L
Abstract excerpt
Acute hepadnavirus infections either resolve or progress to chronicity. Factors that influence chronicity as an outcome of hepatitis B virus (HBV) infection in humans can be studied experimentally in the woodchuck model. Accordingly, several woodchuck hepatitis virus (WHV) inocula were characterized. Representative inocula had high titers of infectious virus (approximately 10(7.7)-10(9.5) woodchuck 50% infectious...
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