Article
Hepadnavirus evolution and molecular strategy of adaptation in a new host.
The Journal of general virology - 1 Mar 1999
Argentini C, La Sorsa V, Bruni R, D'Ugo E, Giuseppetti R, Rapicetta M
Abstract excerpt
In order to elucidate the mechanisms of hepadnavirus evolution in vivo and to trace the fate of known quasispecies in a single animal during the acute phase of infection, a woodchuck (Marmota monax) was infected with the hepadnavirus woodchuck hepatitis B virus (WHV). Woodchuck 197 (W197) was injected intravenously with pooled sera collected from a chronic carrier that had been infected originally with a...
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