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Article

Influence of viral genome properties on polymerase fidelity.

Trends in genetics : TIG - 1 Jan 2023

Dupré Gabriel, Volmer Romain

Abstract excerpt

The first step of viral evolution takes place during genome replication via the error-prone viral polymerase. Among the mutants that arise through this process, only a few well-adapted variants will be selected by natural selection, renewing the viral genome population. Viral polymerase-mediated errors are thought to occur stochastically. However, accumulating evidence suggests that viral polymerase-mediated...

Topics

Mutation
Genome, Viral
Genotype

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

PMID: 36402624
DOI: 10.1016/j.tig.2022.10.008

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