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Article

Reduced expression of TAC1, PENK and SOCS2 in Hcrtr-2 mutated narcoleptic dog brain.

BMC neuroscience - 23 May 2007

Lindberg Julia, Saetre Peter, Nishino Seiji, Mignot Emmanuel, Jazin Elena

Abstract excerpt

BACKGROUND: Narcolepsy causes dramatic behavioral alterations in both humans and dogs, with excessive sleepiness and cataplexy triggered by emotional stimuli. Deficiencies in the hypocretin system are well established as the origin of the condition; both from studies in humans who lack the hypocretin ligand (HCRT) and in dogs with a mutation in hypocretin receptor 2 (HCRTR2). However, little is known about...

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Source

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Identifiers

PMID: 17521418
DOI: 10.1186/1471-2202-8-34
PMCID: PMC1885801

Genes

PENK
TAC1
SOCS2
HCRT
HCRTR2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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