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Article

Interleukin (IL)-12 and IL-23 are key cytokines for immunity against Salmonella in humans.

The Journal of infectious diseases - 15 Nov 2004

MacLennan Calman, Fieschi Claire, Lammas David A, Picard Capucine, Dorman Susan E, Sanal Ozden, MacLennan Jenny M, Holland Steven M, Ottenhoff Tom H M, Casanova Jean-Laurent, Kumararatne Dinakantha S

Abstract excerpt

Patients with inherited deficiency of the interleukin (IL)-12/IL-23-interferon (IFN)- gamma axis show increased susceptibility to invasive disease caused by the intramacrophage pathogens salmonellae and mycobacteria. We analyzed data on 154 patients with such deficiency. Significantly more patients with IL-12/IL-23-component deficiency had a history of salmonella disease than did those with IFN- gamma -component...

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PMID: 15499529
DOI: 10.1086/425021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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