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Article

Epigenome-wide association study for atrazine induced transgenerational DNA methylation and histone retention sperm epigenetic biomarkers for disease.

PloS one - 1 Jan 2020

Thorson Jennifer L M, Beck Daniel, Ben Maamar Millissia, Nilsson Eric E, McBirney Margaux, Skinner Michael K

Abstract excerpt

Atrazine is a common agricultural herbicide previously shown to promote epigenetic transgenerational inheritance of disease to subsequent generations. The current study was designed as an epigenome-wide association study (EWAS) to identify transgenerational sperm disease associated differential DNA methylation regions (DMRs) and differential histone retention regions (DHRs). Gestating female F0 generation rats...

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Identifiers

PMID: 33326428
DOI: 10.1371/journal.pone.0239380
PMCID: PMC7743986

Genes

F3
F2

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