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Article

Herbicide atrazine activates SF-1 by direct affinity and concomitant co-activators recruitments to induce aromatase expression via promoter II.

Biochemical and biophysical research communications - 20 Apr 2007

Fan Wuqiang, Yanase Toshihiko, Morinaga Hidetaka, Gondo Shigeki, Okabe Taijiro, Nomura Masatoshi, Hayes Tyrone B, Takayanagi Ryoichi, Nawata Hajime

Abstract excerpt

The popular herbicide atrazine is an endocrine disruptor that demasculinizes and feminizes several species of animals, and co-relates with breast and reproductive disorders in mammalians. We recently reported that atrazine induces human aromatase gene expression via promoter II (ArPII) in a steroidogenic factor 1 (SF-1)-dependent manner. Here, we show that knockdown of SF-1 abolishes ArPII induction by atrazine...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Cytoplasmic and Nuclear

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Source

Identifiers

PMID: 17331471
DOI: 10.1016/j.bbrc.2007.02.062

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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