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Article

NRAS mutation causes a human autoimmune lymphoproliferative syndrome.

Proceedings of the National Academy of Sciences of the United States of America - 22 May 2007

Oliveira João B, Bidère Nicolas, Niemela Julie E, Zheng Lixin, Sakai Keiko, Nix Cynthia P, Danner Robert L, Barb Jennifer, Munson Peter J, Puck Jennifer M, Dale Janet, Straus Stephen E, Fleisher Thomas A, Lenardo Michael J

Abstract excerpt

The p21 RAS subfamily of small GTPases, including KRAS, HRAS, and NRAS, regulates cell proliferation, cytoskeletal organization, and other signaling networks, and is the most frequent target of activating mutations in cancer. Activating germline mutations of KRAS and HRAS cause severe development...

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Source

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Identifiers

PMID: 17517660
DOI: 10.1073/pnas.0702975104
PMCID: PMC1885609

Genes

NRAS
HRAS
KRAS
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17517660-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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