Article
Somatic KRAS mutations associated with a human nonmalignant syndrome of autoimmunity and abnormal leukocyte homeostasis.
Blood - 10 Mar 2011
Niemela Julie E, Lu Lianghao, Fleisher Thomas A, Davis Joie, Caminha Iusta, Natter Marc, Beer Laurel A, Dowdell Kennichi C, Pittaluga Stefania, Raffeld Mark, Rao V Koneti, Oliveira João B
Abstract excerpt
Somatic gain-of-function mutations in members of the RAS subfamily of small guanosine triphosphatases are found in > 30% of all human cancers. We recently described a syndrome of chronic nonmalignant lymphadenopathy, splenomegaly, and autoimmunity associated with a mutation in NRAS affecting hema...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.