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Article

Evidence for emergence of diverse polioviruses from C-cluster coxsackie A viruses and implications for global poliovirus eradication.

Proceedings of the National Academy of Sciences of the United States of America - 29 May 2007

Jiang Ping, Faase Johan A J, Toyoda Hidemi, Paul Aniko, Wimmer Eckard, Gorbalenya Alexander E

Abstract excerpt

The poliovirus (PV) eradication campaign is conducted on the premise that this virus, because of the lack of a zoonotic reservoir, will not reemerge once eradicated. This report examines the origin of PV using theoretical and experimental approaches. Our rooted phylogenetic analysis suggests a speciation of PV from a C-cluster coxsackie A virus (C-CAV) ancestor through mutation of the capsid that caused a...

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Identifiers

PMID: 17517601
DOI: 10.1073/pnas.0700451104
PMCID: PMC1874223

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