Article
Mutational analysis of immunoglobulin E-binding epitopes of beta-casein and beta-lactoglobulin showed a heterogeneous pattern of critical amino acids between individual patients and pooled sera.
Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology - 1 Jun 2007
Cocco R R, Järvinen K-M, Han N, Beyer K, Sampson H A
Abstract excerpt
BACKGROUND: For immunotherapeutic approaches, 'critical' amino acids (AAs) within allergenic epitopes are replaced with alternate AAs to eliminate IgE antibody binding. OBJECTIVE: To determine the critical AAs for IgE binding in beta-casein and beta-lactoglobulin (BLG). METHODS: Peptides of 10-14...
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