Article
Differential expression of matrix metalloproteinases and inhibitors in developing rat lung mesenchymal and epithelial cells.
Pediatric research - 1 Jul 2007
Boucherat Olivier, Bourbon Jacques R, Barlier-Mur Anne-Marie, Chailley-Heu Bernadette, D'Ortho Marie-Pia, Delacourt Christophe
Abstract excerpt
Lung development requires extracellular matrix remodeling. This involves matrix metalloproteinases (MMPs) and their endogenous inhibitors [tissue inhibitors of metalloproteinases (TIMPs)]. Because these have been generally studied only in whole lung, we focused specifically on mesenchymal and epithelial cells freshly isolated at various developmental stages. In fibroblasts, the most striking developmental change...
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