The single nucleotide polymorphism rs12041948 influences CDX4-Mediated RGS4 gene expression.

doi:10.1016/j.gene.2026.150336

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Article

The single nucleotide polymorphism rs12041948 influences CDX4-Mediated RGS4 gene expression.

Gene - 15 Nov 2026

Xu Feng-Ling, Yang Xin-Rui, Yang Yan-Yan, Wang Rong-Shuai, Liu Li

Abstract excerpt

BACKGROUND: The SNPs in the 5' regulatory region of the human RGS4 gene were reportedly associated with schizophrenia risk. METHODS: To elucidate the impact of the rs12041948 on CDX4 binding and the subsequent regulation of RGS4 gene expression, the dual-luciferase reporter assays, EMSAs, qPCR and western blotting were performed. RESULTS: Haplotypes carrying the rs12041948 T allele exhibited significantly higher...

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PMID: 42542172
DOI: 10.1016/j.gene.2026.150336

Genes

CDX4
RGS4

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