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Article

Cross-linked SecA dimers are not functional in protein translocation.

FEBS letters - 12 Jun 2007

Or Eran, Rapoport Tom

Abstract excerpt

The ATPase SecA is involved in post-translational protein translocation through the SecY channel across the bacterial inner membrane. SecA is a dimer that can dissociate into monomers with translocation activity. Here, we have addressed whether dissociation of the SecA dimer is required for translocation. We show that a dimer in which the two subunits are cross-linked by disulfide bridges is inactive in protein...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17511989
DOI: 10.1016/j.febslet.2007.04.083
PMCID: PMC2755086

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

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Cross-linked SecA dimers are not functional in protein translocation.PMID 17511989Read ↗

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Dimeric SecA is essential for protein translocation.Semantic proximity Read ↗

Bacterial protein translocation requires only one copy of the SecY complex in vivo.Semantic proximity Read ↗

Reexamination of the role of the amino terminus of SecA in promoting its dimerization and functional state.Semantic proximity Read ↗

Quaternary dynamics of the SecA motor drive translocase catalysis.Semantic proximity Read ↗

Escherichia coli SecA truncated at its termini is functional and dimeric.Semantic proximity Read ↗

Nanodiscs unravel the interaction between the SecYEG channel and its cytosolic partner SecA.Semantic proximity Read ↗

Two SecG molecules present in a single protein translocation machinery are functional even after crosslinking.Semantic proximity Read ↗

Multiple SecA molecules drive protein translocation across a single translocon with SecG inversion.Semantic proximity Read ↗

SecY and SecA interact to allow SecA insertion and protein translocation across the Escherichia coli plasma membrane.Semantic proximity Read ↗

Depletion of SecDF-YajC causes a decrease in the level of SecG: implication for their functional interaction.Semantic proximity Read ↗

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