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An evaluation of automated homology modelling methods at low target–template sequence similarity

17 May 2007

Abstract excerpt

MOTIVATION: There are two main areas of difficulty in homology modelling that are particularly important when sequence identity between target and template falls below 50%: sequence alignment and loop building. These problems become magnified with automatic modelling processes, as there is no human input to correct mistakes. As such we have benchmarked several stand-alone strategies that could be implemented in a...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 17510171
DOI: 10.1093/bioinformatics/btm262

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