Article
Phase variation and microevolution at homopolymeric tracts in Bordetella pertussis.
BMC genomics - 17 May 2007
Gogol Emily B, Cummings Craig A, Burns Ryan C, Relman David A
Abstract excerpt
BACKGROUND: Bordetella pertussis, the causative agent of whooping cough, is a highly clonal pathogen of the respiratory tract. Its lack of genetic diversity, relative to many bacterial pathogens, could limit its ability to adapt to a hostile and changing host environment. This limitation might be overcome by phase variation, as observed for other mucosal pathogens. One of the most common mechanisms of phase...
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