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Article

Thermolabilizing pseudoreversions in reovirus outer-capsid protein micro 1 rescue the entry defect conferred by a thermostabilizing mutation.

Journal of virology - 1 Jul 2007

Agosto Melina A, Middleton Jason K, Freimont Elaine C, Yin John, Nibert Max L

Abstract excerpt

Heat-resistant mutants selected from infectious subvirion particles of mammalian reoviruses have determinative mutations in the major outer-capsid protein micro 1. Here we report the isolation and characterization of intragenic pseudoreversions of one such thermostabilizing mutation. From a plaque that had survived heat selection, a number of viruses with one shared mutation but different second-site mutations...

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Identifiers

PMID: 17507494
DOI: 10.1128/JVI.02720-06
PMCID: PMC1933377

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