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Article

Crystal structure of DJ‐1/RS and implication on familial Parkinson's disease1

25 Jul 2003

Abstract excerpt

DJ-1 is a protein involved in multiple physiological processes, including cancer, Parkinson's disease, and male fertility. It is unknown how DJ-1 functions in the apparently different systems. The crystal structure of DJ-1 at 1.6 A resolution shows that DJ-1 is a helix-strand-helix sandwich and forms a dimer. The DJ-1 structure is similar to the members of the intracellular protease PfpI family. However, the...

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PMID: 12914946
DOI: 10.1016/s0014-5793(03)00764-6

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