Article
[Correlations of polymorphisms in matrix metalloproteinase-3 and -7 promoters to susceptibility to brain astrocytoma].
Ai zheng = Aizheng = Chinese journal of cancer - 1 May 2007
Lu Zhong-Qiang, Wang Yi-Min, Cao Yan-Yan, Zhang Qing-Jun, Zhang Xiang-Hong, Li Yue-Hong, Wang Heng-Shu, Xie Hui-Ling, Jiao Bao-Hua, Zhang Jian-Hui
Abstract excerpt
BACKGROUND & OBJECTIVE: Matrix metalloproteinases (MMPs) are key enzymes involved in tumor development, invasion and metastasis. The single nucleotide polymorphisms (SNPs) in the promoter regions of MMP genes may influence tumor development and progression via modulating mRNA transcription and protein expression. This study was to explore the correlations of the promoter SNPs in MMP-3 and MMP-7 genes to...
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