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Article

O6-methylguanine-DNA methyltransferase deficiency in developing brain: implications for brain tumorigenesis.

DNA repair - 1 Aug 2007

Bobola Michael S, Blank A, Berger Mitchel S, Silber John R

Abstract excerpt

The DNA repair protein O(6)-methylguanine-DNA methyltransferase (MGMT) is a cardinal defense against the mutagenic and carcinogenic effects of alkylating agents. We have reported evidence that absence of detectable MGMT activity (MGMT(-) phenotype) in human brain is a predisposing factor for prim...

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Identifiers

PMID: 17500046
DOI: 10.1016/j.dnarep.2007.03.009
PMCID: PMC2692685

Genes

MGMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17500046-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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