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Nucleus Pulposus Cellular Longevity by Telomerase Gene Therapy

1 May 2007

Abstract excerpt

STUDY DESIGN: Nonviral transfection of nucleus pulposus cells with a telomerase expression construct to assess the effects on cellular lifespan, function, karyotypic stability, and transformation properties. OBJECTIVES: To investigate whether telomerase gene therapy can extend the cellular lifespan while retaining functionality of nucleus pulposus cells in a safe manner. SUMMARY OF BACKGROUND DATA: Degeneration...

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PMID: 17495775
DOI: 10.1097/brs.0b013e31805471a3

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