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Telomerase alone extends the replicative life span of human skeletal muscle cells without compromising genomic stability.

Human gene therapy - 10 Oct 2003

Wootton Martha, Steeghs Karen, Watt Diana, Munro June, Gordon Katrina, Ireland Hazel, Morrison Vivienne, Behan Wilhelmina, Parkinson E Kenneth

Abstract excerpt

Continuous cycles of muscle fiber necrosis and regeneration are characteristic of the muscular dystrophies, and in some cases this leads to premature replicative senescence of myoblasts in vitro. The molecular mechanism of senescence in human myoblasts is poorly understood but there is evidence t...

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Identifiers

PMID: 14577927
DOI: 10.1089/104303403769211682

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-14577927-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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Telomerase alone extends the replicative life span of human skeletal muscle cells without compromising genomic stability.PMID 14577927Read ↗

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