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Article

Ultra-Sensitive CSF3R Deep Sequencing in Patients With Severe Congenital Neutropenia

28 Feb 2019

Abstract excerpt

High frequency of acquired CSF3R (colony stimulating factor 3 receptor, granulocyte) mutations has been described in patients with severe congenital neutropenia (CN) at pre-leukemia stage and overt acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). Here, we report the establishment of an ultra-sensitive deep sequencing of a CSF3R segment encoding the intracellular “critical region” of the G-CSFR...

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Identifiers

PMID: 30891028
DOI: 10.3389/fimmu.2019.00116

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