Article
Inherited long QT syndrome revealed by antifungals drug-drug interaction.
Journal of clinical pharmacy and therapeutics - 1 Jun 2007
Eiden C, Peyrière H, Tichit R, Cociglio M, Amedro P, Blayac J-P, Margueritte G, Hillaire-Buys D
Abstract excerpt
A 14-year-old Tahitian girl with acute myeloid leukaemia and a suspected mucormucosis infection was treated with intravenous voriconazole and caspofungin. Because of worsening of fungal infection, voriconazole was switched to posaconazole. During the switch, the patient presented with QT interval prolongation with 'torsades de pointes' and reversible cardiac arrest. Voriconazole plasma level measured 15 h after...
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