Article
Estimating the optimal bottleneck ratio for experimental evolution: the burst-death model.
Mathematical biosciences - 1 Jun 2008
Hubbarde J E, Wahl L M
Abstract excerpt
Population bottlenecks are ubiquitous in nature, and are an inherent feature of the experimental protocol for many laboratory selection experiments. These bottlenecks can have profound effects on the rate and trajectory of evolution. In particular, there is a trade-off between sampling the population too frequently and imposing infrequent, but more severe, bottlenecks. In this paper we consider the effects of...
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