Article
In vivo p53 response and immune reaction underlie highly effective low-dose radiotherapy in follicular lymphoma.
Blood - 15 Aug 2007
Knoops Laurent, Haas Rick, de Kemp Sanne, Majoor Donné, Broeks Annegien, Eldering Eric, de Boer Jan Paul, Verheij Marcel, van Ostrom Conny, de Vries Annemieke, van't Veer Laura, de Jong Daphne
Abstract excerpt
Very low-dose irradiation (2 x 2 Gy) is a new, effective, and safe local treatment for follicular lymphoma. To understand the biologic mechanisms of this extremely effective response, we compared by microarray the gene-expression profile of patients' biopsies taken before and after radiation. In all patients, a major and consistent induction of p53 target genes was seen. p53 targets involved in cell-cycle arrest...
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