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Article

Tryptanthrin inhibits MDR1 and reverses doxorubicin resistance in breast cancer cells.

Biochemical and biophysical research communications - 22 Jun 2007

Yu Sung-Tsai, Chen Tzer-Ming, Tseng Shih-Yun, Chen Yen-Hui

Abstract excerpt

Development of agents to overcome multidrug resistance (MDR) is important in cancer chemotherapy. Up to date, few chemicals have been reported to down-regulate MDR1 gene expression. We evaluated the effect of tryptanthrin on P-glycoprotein (P-gp)-mediated MDR in a breast cancer cell line MCF-7. T...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 17482571
DOI: 10.1016/j.bbrc.2007.04.107

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-17482571-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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