Article
Association of killer cell immunoglobulin-like receptor genes with Hodgkin's lymphoma in a familial study.
PloS one - 2 May 2007
Besson Caroline, Roetynck Sophie, Williams Fionnuala, Orsi Laurent, Amiel Corinne, Lependeven Catherine, Antoni Guillemette, Hermine Olivier, Brice Pauline, Ferme Christophe, Carde Patrice, Canioni Danielle, Brière Josette, Raphael Martine, Nicolas Jean-Claude, Clavel Jacqueline, Middleton Derek, Vivier Eric, Abel Laurent
Abstract excerpt
BACKGROUND: Epstein-Barr virus (EBV) is the major environmental factor associated with Hodgkin's lymphoma (HL), a common lymphoma in young adults. Natural killer (NK) cells are key actors of the innate immune response against viruses. The regulation of NK cell function involves activating and inhibitory Killer cell Immunoglobulin-like receptors (KIRs), which are expressed in variable numbers on NK cells. Various...
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