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Relationship between insulin sensitivity and gene expression in human skeletal muscle

27 Feb 2021

Abstract excerpt

BACKGROUND: Insulin resistance (IR) in skeletal muscle is a key feature of the pre-diabetic state, hypertension, dyslipidemia, cardiovascular diseases and also predicts type 2 diabetes. However, the underlying molecular mechanisms are still poorly understood. METHODS: To explore these mechanisms, we related global skeletal muscle gene expression profiling of 38 non-diabetic men to a surrogate measure of insulin...

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PMID: 33639916
DOI: 10.1186/s12902-021-00687-9

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