Article
Mechanism of cell surface expression of the Streptococcus mitis platelet binding proteins PblA and PblB.
Molecular microbiology - 1 May 2007
Mitchell Jennifer, Siboo Ian R, Takamatsu Daisuke, Chambers Henry F, Sullam Paul M
Abstract excerpt
PblA and PblB are prophage-encoded proteins of Streptococcus mitis strain SF100 that mediate binding to human platelets. The mechanism for surface expression of these proteins has been unknown, as they do not contain signal sequences or cell wall sorting motifs. We therefore assessed whether expression of these proteins was linked the lytic cycle of the prophage. Deletion of either the holin or lysin gene...
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