Article
[Anticancer drug dosing--pharmacogenomic biomarkers or body surface area?].
Tidsskrift for den Norske laegeforening : tidsskrift for praktisk medicin, ny raekke - 19 Apr 2007
Lehne Gustav, Bjørheim Jens, Saeter Gunnar
Abstract excerpt
BACKGROUND: Chemotherapeutic treatment regimes are established for most cancer forms. In general, these substances have extremely narrow therapeutic windows, which render cancer patients vulnerable to over- and underdosing. Individual drug dosing is currently based on the patients' body surface area. This practice is an extrapolation from animal studies. Recent advances in molecular medicine raise the question of...
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