Estrogen-Enhanced Peptidylarginine Deiminase Type IV Gene (<i>PADI4</i>) Expression in MCF-7 Cells Is Mediated by Estrogen Receptor-α-Promoted Transfactors Activator Protein-1, Nuclear Factor-Y, and Sp1

Abstract excerpt

Human peptidylarginine deiminase type IV (PAD4), a Ca(2+)-dependent enzyme known to convert arginine residues to citrulline residues in histones, has been shown to be associated with the development of rheumatoid arthritis. Recently, it was noted that the human peptidylarginine deiminase type IV gene (PADI4) regulates the expression of estrogen-responsive genes by modifying the methylated arginine sites in...

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