Article
Patients with an unexplained microsatellite instable tumour have a low risk of familial cancer.
British journal of cancer - 21 May 2007
Overbeek L I H, Kets C M, Hebeda K M, Bodmer D, van der Looij E, Willems R, Goossens M, Arts N, Brunner H G, van Krieken J H J M, Hoogerbrugge N, Ligtenberg M J L
Abstract excerpt
The cancer risk is unknown for those families in which a microsatellite instable tumour is neither explained by MLH1 promoter methylation nor by a germline mutation in a mismatch repair (MMR) gene. Such information is essential for genetic counselling. Families suspected of Lynch syndrome (n = 614) were analysed for microsatellite instability, MLH1 promoter methylation and/or germline mutations in MLH1, MSH2,...
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