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In silico mining identifies IGFBP3 as a novel target of methylation in prostate cancer

24 Apr 2007

Abstract excerpt

Promoter hypermethylation is central in deregulating gene expression in cancer. Identification of novel methylation targets in specific cancers provides a basis for their use as biomarkers of disease occurrence and progression. We developed an in silico strategy to globally identify potential targets of promoter hypermethylation in prostate cancer by screening for 5' CpG islands in 631 genes that were reported as...

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PMID: 17453001
DOI: 10.1038/sj.bjc.6603767

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