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Article

A three‐gene DNA methylation biomarker accurately classifies early stage prostate cancer

21 Aug 2019

Abstract excerpt

BACKGROUND: We identify and validate accurate diagnostic biomarkers for prostate cancer through a systematic evaluation of DNA methylation alterations. MATERIALS AND METHODS: We assembled three early prostate cancer cohorts (total patients = 699) from which we collected and processed over 1300 prostatectomy tissue samples for DNA extraction. Using real-time methylation-specific PCR, we measured normalized...

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PMID: 31433512
DOI: 10.1002/pros.23895

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