Article
Dileucine motif is sufficient for internalization and synaptic vesicle targeting of vesicular acetylcholine transporter.
Traffic (Copenhagen, Denmark) - 1 May 2007
Colgan Lesley, Liu Hao, Huang Steven Y, Liu Yong-Jian
Abstract excerpt
Efficient cholinergic transmission requires accurate targeting of vesicular acetylcholine transporter (VAChT) to synaptic vesicles (SVs). However, the signals that regulate this vesicular targeting are not well characterized. Although previous studies suggest that the C-terminus of the transporter is required for its SV targeting, it is not clear whether this region is sufficient for this process. Furthermore, a...
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