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Article

Diverted Total Synthesis of Carolacton-Inspired Analogs Yields Three Distinct Phenotypes in Streptococcus mutans Biofilms.

Journal of the American Chemical Society - 31 May 2017

Solinski Amy E, Koval Alexander B, Brzozowski Richard S, Morrison Kelly R, Fraboni Americo J, Carson Carrie E, Eshraghi Anisa R, Zhou Guangfeng, Quivey Robert G, Voelz Vincent A, Buttaro Bettina A, Wuest William M

Abstract excerpt

The oral microbiome is a dynamic environment inhabited by both commensals and pathogens. Among these is Streptococcus mutans, the causative agent of dental caries, the most prevalent childhood disease. Carolacton has remarkably specific activity against S. mutans, causing acid-mediated cell death during biofilm formation; however, its complex structure limits its utility. Herein, we report the diverted total...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 28502178
DOI: 10.1021/jacs.7b03879
PMCID: PMC5891724

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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