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Article

Dissecting the anti-desmoglein autoreactive B cell repertoire in pemphigus vulgaris patients.

Journal of immunology (Baltimore, Md. : 1950) - 1 May 2007

Qian Ye, Diaz Luis A, Ye Jian, Clarke Stephen H

Abstract excerpt

Pemphigus vulgaris (PV) encompasses two clinical phenotypes, one producing mucosal blisters and the other mucosal and skin lesions (mcPV). The mucosal blister-producing PV variant is characterized by autoantibodies against desmoglein (Dsg)3, whereas mucosal and skin lesion-producing PV is characterized by autoantibodies to Dsg3 and Dsg1. The present study was aimed at disclosing the diversity and clonality of the...

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Source

Identifiers

PMID: 17442983
DOI: 10.4049/jimmunol.178.9.5982

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

Related research

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Dissecting the anti-desmoglein autoreactive B cell repertoire in pemphigus vulgaris patients.PMID 17442983Read ↗

Analysis of the T cells that are potentially involved in autoantibody production in pemphigus vulgaris.Semantic proximity Read ↗

Heterogeneous MHC II restriction pattern of autoreactive desmoglein 3 specific T cell responses in pemphigus vulgaris patients and normals.Semantic proximity Read ↗

Multiplexed autoantigen microarrays identify HLA as a key driver of anti-desmoglein and -non-desmoglein reactivities in pemphigusSemantic proximity Read ↗

A Single Helper T Cell Clone Is Sufficient to Commit Polyclonal Naive B Cells to Produce Pathogenic IgG in Experimental Pemphigus VulgarisSemantic proximity Read ↗

Immune response in pemphigus and beyond: progresses and emerging concepts.Semantic proximity Read ↗

Dichotomy of Autoreactive Th1 and Th2 Cell Responses to Desmoglein 3 in Patients with Pemphigus Vulgaris (PV) and Healthy Carriers of PV-Associated HLA Class II AllelesSemantic proximity Read ↗

Mucosal pemphigus vulgaris anti-Dsg3 IgG is pathogenic to the oral mucosa of humanized Dsg3 mice.Semantic proximity Read ↗

Beyond the skin: B cells in pemphigus vulgaris, tolerance and treatmentSemantic proximity Read ↗

Novel System Evaluating In Vivo Pathogenicity of Desmoglein 3-Reactive T Cell Clones Using Murine Pemphigus VulgarisSemantic proximity Read ↗

Autoantibody Signaling in Pemphigus Vulgaris: Development of an Integrated ModelSemantic proximity Read ↗

Conformational epitope mapping of antibodies against desmoglein 3 in experimental murine pemphigus vulgaris.Semantic proximity Read ↗

The Genetics of Pemphigus VulgarisSemantic proximity Read ↗

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