Effects of gene mutations in lipoprotein and hepatic lipases as interpreted by a molecular model of the pancreatic triglyceride lipase.

Article

Effects of gene mutations in lipoprotein and hepatic lipases as interpreted by a molecular model of the pancreatic triglyceride lipase.

The Journal of biological chemistry - 5 Dec 1991

Derewenda Z S, Cambillau C

Abstract excerpt

A molecular model of human pancreatic lipase (Winkler, F. K., D'Arcy, A., and Hunziker, W. (1990) Nature 343, 771-774) is used to explain the possible structural effects of the amino acid mutations identified to date in the human lipoprotein and hepatic lipase genes. A sequence homology profile w...

Topics

Amino Acid Sequence
Humans
Lipase
Lipoprotein Lipase
Liver
Models, Molecular
Molecular Sequence Data
Mutation
Pancreas
Sequence Alignment
Structure-Activity Relationship

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