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Article

The 1p-Encoded Protein Stathmin and Resistance of Malignant Gliomas to Nitrosoureas

17 Apr 2007

Abstract excerpt

BACKGROUND: Malignant gliomas are generally resistant to all conventional therapies. Notable exceptions are anaplastic oligodendrogliomas with loss of heterozygosity on chromosome 1p (1p+/-). Patients with 1p+/- anaplastic oligodendroglioma frequently respond to procarbazine, 1-(2-chloroethyl)-3-cyclohexyl-l-nitrosourea, and vincristine. Because the underlying biologic basis for this clinical finding is unclear,...

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Identifiers

PMID: 17440165
DOI: 10.1093/jnci/djk135

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Source receipt: pubmed, retrieved 7 Sept 2026.

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