Article
A single nucleotide mutation in Nppc is associated with a long bone abnormality in lbab mice.
BMC genetics - 17 Apr 2007
Jiao Yan, Yan Jian, Jiao Feng, Yang Hongbin, Donahue Leah Rae, Li Xinmin, Roe Bruce A, Stuart John, Gu Weikuan
Abstract excerpt
BACKGROUND: The long bone abnormality (lbab) mouse is a new autosomal recessive mutant characterized by overall smaller body size with proportionate dwarfing of all organs and shorter long bones. Previous linkage analysis has located the lbab mutation on chromosome 1 between the markers D1Mit9 and D1Mit488. RESULTS: A genome-based positional approach was used to identify a mutation associated with lbab disease. A...
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