Article
Age-specific association of steroid hormone pathway gene polymorphisms with breast cancer risk.
Cancer - 15 May 2007
Ralph David A, Zhao Lue Ping, Aston Christopher E, Manjeshwar Sharmila, Pugh Thomas W, DeFreese Daniele C, Gramling Bobby A, Shimasaki Craig D, Jupe Eldon R
Abstract excerpt
BACKGROUND: Breast cancer (BC) is a complex disease, and the incidence rates for BC increase with age. Both environmental factors and genetics have an impact on the risk of BC. Although the effects of environmental factors may vary with age, it has been assumed generally that the penetrance of single nucleotide polymorphisms (SNPs) is constant throughout life. In the current study, the results demonstrated that...
Topics
- Adult
- Aged
- Aging
- Aromatase
- Breast Neoplasms
- Catechol O-Methyltransferase
- Cytochrome P-450 CYP11B2
- Female
- Genetic Predisposition to Disease
- Glucuronosyltransferase
- Gonadal Steroid Hormones
- Humans
- Middle Aged