Article
Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia.
Nature genetics - 1 May 2007
Lahortiga Idoya, De Keersmaecker Kim, Van Vlierberghe Pieter, Graux Carlos, Cauwelier Barbara, Lambert Frederic, Mentens Nicole, Beverloo H Berna, Pieters Rob, Speleman Frank, Odero Maria D, Bauters Marijke, Froyen Guy, Marynen Peter, Vandenberghe Peter, Wlodarska Iwona, Meijerink Jules P P, Cools Jan
Abstract excerpt
We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our re...
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