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Article

Surprising production of a new urdamycin derivative by S. fradiae Delta urdQ/R.

Journal of biotechnology - 31 May 2007

Fedoryshyn M, Nur-e-Alam M, Zhu L, Luzhetskyy A, Rohr J, Bechthold A

Abstract excerpt

A strain (S. fradiae Delta urdQ/R) with mutations in urdQ and urdR encoding a dTDP-hexose-3,4-dehydratase and a dTDP-hexose-4-ketoreductase, respectively, produces a new urdamycin analogue (urdamycin X) with changes in the polyketide structure. The structure of urdamycin X has been elucidated by NMR spectroscopy. Urdamycin X was not detectable, even in small amounts, in either S. fradiae Delta urdQ, in S. fradiae...

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Identifiers

PMID: 17434221
DOI: 10.1016/j.jbiotec.2007.02.018
PMCID: PMC2880504

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