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Article

The role of ABC-transporter gene polymorphisms in chemotherapy induced immunosuppression, a retrospective study in childhood acute lymphoblastic leukaemia.

Cellular immunology - 1 Dec 2006

Erdélyi Dániel J, Kámory Eniko, Zalka Anna, Semsei Agnes F, Csókay Béla, Andrikovics Hajnalka, Tordai Attila, Borgulya Gábor, Magyarosy Edina, Galántai Ilona, Fekete György, Falus András, Szalai Csaba, Kovács Gábor T

Abstract excerpt

We examined the association of functional ABCB1 (MDR1) and ABCG2 (BCRP) polymorphisms with acute side effects of chemotherapy. Analyses were performed on clinical data from 138 patients treated with the ALL-BFM-95 protocol implying several substrates of these transporters. ABCB1 3435T>C, 2677G>T/A 1236C>T and ABCG2 421C>A genotypes were determined. A higher proportion of ABCB1 3435TT patients suffered excessive...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Source

Identifiers

PMID: 17434155
DOI: 10.1016/j.cellimm.2007.02.007

Genes

ABCB1
ABCG2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The role of ABC-transporter gene polymorphisms in chemotherapy induced immunosuppression, a retrospective study in childhood acute lymphoblastic leukaemia.PMID 17434155Read ↗

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