Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene.

Brain research - 30 May 2007

Murakami Tetsuro, Nagai Makiko, Miyazaki Kazunori, Morimoto Nobutoshi, Ohta Yasuyuki, Kurata Tomoko, Takehisa Yasushi, Kamiya Tatsushi, Abe Koji

Abstract excerpt

Growing evidence has recently shown that mutant SOD1 accumulate in the mitochondria and cause vacuolation in transgenic mice carrying mutant SOD1, an animal model of amyotrophic lateral sclerosis (ALS). In this study, the expressions of DNA repair enzymes, oxoguanine glycosylase 1 (ogg1), DNA pol...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA-Directed DNA Polymerase
Share to DNA Glycosylases
Share to DNA Polymerase beta

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Polymerase gamma

Share to DNA Repair Enzymes

Share to Motor Neurons

Share to Spinal Cord

Share to Superoxide Dismutase

Source

Identifiers

PMID: 17434152
DOI: 10.1016/j.brainres.2007.02.057

Genes

SOD1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17434152-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early decrease of mitochondrial DNA repair enzymes in spinal motor neurons of presymptomatic transgenic mice carrying a mutant SOD1 gene.PMID 17434152Read ↗

Early decrease of redox factor-1 in spinal motor neurons of presymptomatic transgenic mice with a mutant SOD1 gene.Semantic proximity Read ↗

Ultrastructural study of mitochondria in the spinal cord of transgenic mice with a G93A mutant SOD1 gene.Semantic proximity Read ↗

Cytoplasmic Restriction of Mutated SOD1 Impairs the DNA Repair Process in Spinal Cord Neurons.Semantic proximity Read ↗

Ultrastructural changes in lumbar spinal cord in transgenic SOD1G93A rats.Semantic proximity Read ↗

Aggregates of mutant protein appear progressively in dendrites, in periaxonal processes of oligodendrocytes, and in neuronal and astrocytic perikarya of mice expressing the SOD1(G93A) mutation of familial amyotrophic lateral sclerosis.Semantic proximity Read ↗

Mutation of SOD1 in ALS: a gain of a loss of function.Semantic proximity Read ↗

The Golgi apparatus of spinal cord motor neurons in transgenic mice expressing mutant Cu,Zn superoxide dismutase becomes fragmented in early, preclinical stages of the disease.Semantic proximity Read ↗

Decreased mRNA Expression of PGC-1α and PGC-1α-Regulated Factors in the SOD1<sup>G93A</sup>ALS Mouse Model and in Human Sporadic ALSSemantic proximity Read ↗

Change in superoxide dismutase 1 protein localization towards mitochondria: an immunohistochemical study in transgenic G93A mice.Semantic proximity Read ↗

Ultrastructural study of aggregates in the spinal cord of transgenic mice with a G93A mutant SOD1 geneSemantic proximity Read ↗

Immunohistochemical study on the distribution of MnSOD in the central nervous system of the transgenic mice expressing a human Cu/Zn SOD mutation.Semantic proximity Read ↗

Decreased mtDNA, oxidative stress, cardiomyopathy, and death from transgenic cardiac targeted human mutant polymerase gamma.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.