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Article

Empirical evaluation of selective DNA pooling to map QTL in dairy cattle using a half-sib design by comparison to individual genotyping and interval mapping.

Genetics, selection, evolution : GSE - 1 Jan 2000

Mariasegaram Maxy, Robinson Nicholas Andrew, Goddard Michael Edward

Abstract excerpt

This study represents the first attempt at an empirical evaluation of the DNA pooling methodology by comparing it to individual genotyping and interval mapping to detect QTL in a dairy half-sib design. The findings indicated that the use of peak heights from the pool electropherograms without correction for stutter (shadow) product and preferential amplification performed as well as corrected estimates of...

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PMID: 17433241
DOI: 10.1186/1297-9686-39-3-267
PMCID: PMC2682826

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